Treatment of Ifosfamide -induced Encephalopathy with Methylene Blue in an Adolescent with Relapsed Acute Lymphoblastic Leukemia: a case report

Authors

  • GH Miri aliabad Fellow of Pediatric Hematology-Oncology, Tehran University of Medical Sciences, Tehran, Iran
  • KH Arjomandi Associate Professor of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.
  • S Yousefiyan Fellow of Pediatric Hematology-Oncology, Tehran University of Medical Sciences, Tehran, Iran
Abstract:

Ifosfamide is one of the most important chemotherapeutic agents used for the treatment of numerous types of malignancies. Neurotoxicity is one of its life-threatening complications and is potentially fatal. In this paper we present a case of severe ifosfamide- induced encephalopathy in an adolescent with acute lymphoblastic leukemia in whom treatment with methylene blue led to complete improvement of neurologic symptoms.

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Journal title

volume 20  issue 3

pages  326- 330

publication date 2013-07-01

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